| First Author | Ishii N | Year | 1996 |
| Journal | Brain Res Mol Brain Res | Volume | 40 |
| Issue | 1 | Pages | 148-52 |
| PubMed ID | 8840024 | Mgi Jnum | J:34360 |
| Mgi Id | MGI:81820 | Doi | 10.1016/0169-328x(96)00090-3 |
| Citation | Ishii N, et al. (1996) Increased expression of NLRR-3 mRNA after cortical brain injury in mouse. Brain Res Mol Brain Res 40(1):148-52 |
| abstractText | In Drosophila, members of the leucine-rich repeat (LRR) family have significant functions in neural development. We have isolated mouse brain cDNAs which encode three new independent LRR proteins (neuronal leucine-rich repeat: NLRR-1, NLRR-2, NLRR-3). Levels of expression of these NLRR mRNAs were measured in a unilateral cortical injury model by in-situ hybridization and Northern blot analysis. In the injured cerebral cortex, only NLRR-3 mRNA increased in layers 2-3, while the other two genes showed no up-regulation. The level of NLRR-3 mRNA induction peaked around 7-10 days postinjury. This study suggests that NLRR-3 may be an important component of the pathophysiological response to brain injury. |
