| First Author | Collin R | Year | 2020 |
| Journal | J Immunol | Volume | 205 |
| Issue | 1 | Pages | 133-142 |
| PubMed ID | 32434937 | Mgi Jnum | J:293389 |
| Mgi Id | MGI:6445087 | Doi | 10.4049/jimmunol.2000156 |
| Citation | Collin R, et al. (2020) MHC-Independent Thymic Selection of CD4 and CD8 Coreceptor Negative alphabeta T Cells. J Immunol 205(1):133-142 |
| abstractText | It is becoming increasingly clear that unconventional T cell subsets, such as NKT, gammadelta T, mucosal-associated invariant T, and CD8alphaalpha T cells, each play distinct roles in the immune response. Subsets of these cell types can lack both CD4 and CD8 coreceptor expression. Beyond these known subsets, we identify CD4(-)CD8(-)TCRalphabeta(+), double-negative (DN) T cells, in mouse secondary lymphoid organs. DN T cells are a unique unconventional thymic-derived T cell subset. In contrast to CD5(high) DN thymocytes that preferentially yield TCRalphabeta(+) CD8alphaalpha intestinal lymphocytes, we find that mature CD5(low) DN thymocytes are precursors to peripheral DN T cells. Using reporter mouse strains, we show that DN T cells transit through the immature CD4(+)CD8(+) (double-positive) thymocyte stage. Moreover, we provide evidence that DN T cells can differentiate in MHC-deficient mice. Our study demonstrates that MHC-independent thymic selection can yield DN T cells that are distinct from NKT, gammadelta T, mucosal-associated invariant T, and CD8alphaalpha T cells. |
