| First Author | MacCalman CD | Year | 1995 |
| Journal | Dev Genet | Volume | 16 |
| Issue | 1 | Pages | 20-4 |
| PubMed ID | 7758243 | Mgi Jnum | J:24065 |
| Mgi Id | MGI:71812 | Doi | 10.1002/dvg.1020160106 |
| Citation | MacCalman CD, et al. (1995) Estradiol regulates N-cadherin mRNA levels in the mouse ovary. Dev Genet 16(1):20-4 |
| abstractText | N-cadherin (N-cad) is a calcium-dependent cell adhesion molecule which is present in the granulosa cells of the mouse ovarian follicle. This cell adhesion molecule has been implicated as a key modulator of follicular development. The regulators of N-cad mRNA levels in the ovary have not been identified. We have examined the ability of steroids to influence ovarian N-cad mRNA levels in vivo. Immature mice were injected with either progesterone, testosterone, 17 beta-estradiol, or 17 alpha-estradiol. Only 17 beta-estradiol caused a rapid and significant increase in the ovarian N-cad mRNA levels. We speculate that this steroid is a major regulator of N-cad-mediated granulosa cell interactions in vivo. |
