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Protein Coding Gene : Semg1 semenogelin 1
Primary Identifier  MGI:1858275 Organism  mouse, laboratory
Chromosome  2 NCBI Gene Number  53878
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable protease binding activity and zinc ion binding activity. Acts upstream of or within fertilization and sperm capacitation. Located in acrosomal vesicle. Is expressed in alimentary system; bladder; and male reproductive gland or organ. Orthologous to human SEMG1 (semenogelin 1) and SEMG2 (semenogelin 2).
PHENOTYPE: Male mice homozygous for a null allele display severely reduced fertility with premature acrosome reaction, absence of copulatory plug formation and intrauterine death of sperm. [provided by MGI curators]
  • synonyms:
  • semenogelin I,
  • Semg1,
  • expressed sequence BB115391,
  • semenoclotin,
  • SVS II,
  • MGI:2139431,
  • BB115391,
  • seminal vesicle secretory protein 2,
  • Svs2,
  • semenogelin 1
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