Primary Identifier | MGI:2651590 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Gpx4 |
Transmission | Germline | Strain of Origin | 129S7/SvEvBrd-Hprt1<b-m2> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Exons 3 through 7 of the endogenous gene were replaced with an hprt cassette inserted by homologous recombination. Transcript and protein levels were reduced by approximately 50% relative to wild-type levels in heart, liver, kidney, brain, and testes tissues. |