| First Author | Jiang P | Year | 1999 |
| Journal | J Biol Chem | Volume | 274 |
| Issue | 2 | Pages | 559-62 |
| PubMed ID | 9872987 | Mgi Jnum | J:52073 |
| Mgi Id | MGI:1327775 | Doi | 10.1074/jbc.274.2.559 |
| Citation | Jiang P, et al. (1999) Integrin-associated protein is a ligand for the P84 neural adhesion molecule. J Biol Chem 274(2):559-62 |
| abstractText | P84 (also known as SHPS-1, BIT, and SIRP) is a heterophilic adhesive membrane protein involved in receptor tyrosine kinase signaling that is found at synapses in the mammalian central nervous system and in non-neural tissues. We have identified a binding partner for P84 using an expression cloning strategy. Here we report that integrin-associated protein (IAP/CD47) is a predominant binding partner of P84. Immunohistochemistry reveals a virtually identical distribution of P84 and IAP in a variety of adult brain regions. Because IAP has been implicated in cell signaling in cells of the immune system, P84 and IAP represent a heterophilic binding pair that is likely to be involved in bi-directional signaling at the synapse and in other tissues. |
