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Protein Coding Gene : Grin3a glutamate receptor ionotropic, NMDA3A
Primary Identifier  MGI:1933206 Organism  mouse, laboratory
Chromosome  4 NCBI Gene Number  242443
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Enables NMDA glutamate receptor activity; calcium channel activity; and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Involved in presynaptic modulation of chemical synaptic transmission. Acts upstream of or within calcium ion transport; dendrite development; and prepulse inhibition. Located in neuronal cell body and postsynaptic membrane. Is active in glutamatergic synapse. Is expressed in several structures, including adrenal gland; alimentary system; central nervous system; foot bone; and hand mesenchyme. Orthologous to human GRIN3A (glutamate ionotropic receptor NMDA type subunit 3A).
PHENOTYPE: Mice homozygous for a disruption in this gene display increased current densities in some cerebrocortical neurons of the brain, increased levels of prepulse inhibition, and altered dendritic spine morphology. Otherwise, they display a normal phenotype. [provided by MGI curators]
  • synonyms:
  • NMDAR-L,
  • Grin3a,
  • RIKEN cDNA A830097C19 gene,
  • A830097C19Rik,
  • NR3A,
  • MGI:3036253,
  • glutamate receptor ionotropic, NMDA3A
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