| First Author | Koop BF | Year | 1994 |
| Journal | Nat Genet | Volume | 7 |
| Issue | 1 | Pages | 48-53 |
| PubMed ID | 8075639 | Mgi Jnum | J:17988 |
| Mgi Id | MGI:66011 | Doi | 10.1038/ng0594-48 |
| Citation | Koop BF, et al. (1994) Striking sequence similarity over almost 100 kilobases of human and mouse T-cell receptor DNA. Nat Genet 7(1):48-53 |
| abstractText | We report here the comparative DNA sequence analysis of nearly 100 kilobases of contiguous DNA in the C delta to C alpha region of the alpha/delta T cell receptor loci (TCRAC/TCRDC) of mouse and man. This analysis--the largest genomic sequence comparison so far--provides new insights into the functions of the T cell receptor genes as well as the surrounding chromosome structure through the identification of actively conserved DNA sequences. In this comparison we have identified a very high level of organizational and noncoding sequence similarity (approximately 71%) in contrast to previous findings in the beta-globin gene cluster. This observation begins to question the notion that much of the chromosomal non-coding sequence is junk. |
