| Primary Identifier | MGI:1347046 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 26374 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; and response to ionizing radiation. Predicted to be located in Golgi membrane. Predicted to be part of Cul4A-RING E3 ubiquitin ligase complex. Is expressed in several structures, including central nervous system; genitourinary system; limb; and liver. Orthologous to human COP1 (COP1 E3 ubiquitin ligase). PHENOTYPE: Mice homozygous for a conditional allele activated in prostate epithelial cells exhibit prostate gland hyperplasia and prostate intraepithelial neoplasia due to increased cell proliferation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
