First Author | Tao RH | Year | 2006 |
Journal | Biochem Biophys Res Commun | Volume | 341 |
Issue | 2 | Pages | 515-21 |
PubMed ID | 16446156 | Mgi Jnum | J:252006 |
Mgi Id | MGI:6107468 | Doi | 10.1016/j.bbrc.2005.12.213 |
Citation | Tao RH, et al. (2006) Opposite effects of alternative TZF spliced variants on androgen receptor. Biochem Biophys Res Commun 341(2):515-21 |
abstractText | We previously demonstrated that testicular zinc-finger protein (TZF) was a corepressor of the androgen receptor (AR). In the present study, we further showed that TZF-L, an alternative spliced variant of TZF, enhanced transactivation function of AR. Deletion analysis of TZF-L revealed that its N-terminus, which almost corresponded to that of TZF, but not its C-terminus was able to interact with AR. Additional analysis suggested that TZF and TZF-L were able to form both homodimers and heterodimers. TZF-L inhibited the homodimer formation of TZF and the intranuclear dot formation of TZF. We propose that in the unique regulation system of AR-mediated transactivation, two spliced isoforms of TZF act as coactivator and corepressor, respectively. |