|  Help  |  About  |  Contact Us

Publication : AKAP9 is essential for spermatogenesis and sertoli cell maturation in mice.

First Author  Schimenti KJ Year  2013
Journal  Genetics Volume  194
Issue  2 Pages  447-57
PubMed ID  23608191 Mgi Jnum  J:198499
Mgi Id  MGI:5496944 Doi  10.1534/genetics.113.150789
Citation  Schimenti KJ, et al. (2013) AKAP9 is essential for spermatogenesis and sertoli cell maturation in mice. Genetics 194(2):447-57
abstractText  Mammalian male fertility relies on complex inter- and intracellular signaling during spermatogenesis. Here we describe three alleles of the widely expressed A-kinase anchoring protein 9 (Akap9) gene, all of which cause gametogenic failure and infertility in the absence of marked somatic phenotypes. Akap9 disruption does not affect spindle nucleation or progression of prophase I of meiosis but does inhibit maturation of Sertoli cells, which continue to express the immaturity markers anti-Mullerian hormone and thyroid hormone receptor alpha in adults and fail to express the maturation marker p27(Kip1). Furthermore, gap and tight junctions essential for blood-testis barrier (BTB) organization are disrupted. Connexin43 (Cx43) and zona occludens-1 are improperly localized in Akap9 mutant testes, and Cx43 fails to compartmentalize germ cells near the BTB. These results identify and support a novel reproductive tissue-specific role for Akap9 in the coordinated regulation of Sertoli cells in the testis.
Quick Links:
 
Quick Links:
 

Expression

Publication --> Expression annotations

 

Other

14 Bio Entities

Trail: Publication

0 Expression