| First Author | Moll J | Year | 1991 |
| Journal | Oncogene | Volume | 6 |
| Issue | 5 | Pages | 863-6 |
| PubMed ID | 1905006 | Mgi Jnum | J:724 |
| Mgi Id | MGI:49258 | Citation | Moll J, et al. (1991) The murine rac1 gene: cDNA cloning, tissue distribution and regulated expression of rac1 mRNA by disassembly of actin microfilaments. Oncogene 6(5):863-6 |
| abstractText | A 886 bp cDNA encoding the murine rac1 protein has been isolated. The abundance of rac1 mRNA was determined in fourteen tissues from both mouse and pig. The mRNA 5' non-coding sequence is very rich in G + C, and has the potential to form several stable secondary structures. In addition, this region contains a putative open reading frame of 57 amino acids. Disruption of the actin microfilament network by cytochalasin B in LLC-PK1 cells results in down regulation of rac1 mRNA. In agreement with the proposed role of rac1 in exocytosis, these results could explain the inhibitory effect of cytochalasin B on secretory processes. |
