| First Author | Crocker SJ | Year | 2003 |
| Journal | Neurobiol Dis | Volume | 12 |
| Issue | 2 | Pages | 150-61 |
| PubMed ID | 12667469 | Mgi Jnum | J:131674 |
| Mgi Id | MGI:3774196 | Doi | 10.1016/s0969-9961(02)00020-7 |
| Citation | Crocker SJ, et al. (2003) Attenuation of MPTP-induced neurotoxicity and behavioural impairment in NSE-XIAP transgenic mice. Neurobiol Dis 12(2):150-61 |
| abstractText | X-linked IAP protein is a potent inhibitor of cell death. Here, we describe a novel transgenic mouse in which the human XIAP gene is expressed under the control of the neuron-specific enolase promoter (NSE-xiap). We demonstrate that nigrostriatal dopamine neurons of NSE-xiap mice were resistant to the damaging effects of the dopaminergic neurotoxin MPTP. MPTP-induced reduction of striatal dopamine metabolism was also attenuated in NSE-xiap mice. Furthermore, NSE-xiap mice treated with MPTP did not exhibit deficits in exploratory behaviour in an open-field test. Taken together, these findings suggest that strategies to enhance neuronal expression of XIAP may provide therapeutic benefit for the treatment of neurodegeneration in Parkinson's disease. |
