| Primary Identifier | MGI:2388490 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Nqo1 |
| Transmission | Germline | Strain of Origin | 129/Sv |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exon 6 and flanking non-coding sequences were replaced with a 2 kb neomycin resistance cassette via homologous recombination. The targeted mutation results in deletion of 101 C-terminal residues and disrupts enzyme function. Gene expression was absent in homozygous mutant animals in all tissues examined (lung, liver, kidney, colong, skeletal muscle) by Northern blot and Western blot. |
