| First Author | Thomson RB | Year | 1998 |
| Journal | Genomics | Volume | 51 |
| Issue | 3 | Pages | 445-51 |
| PubMed ID | 9721215 | Mgi Jnum | J:49767 |
| Mgi Id | MGI:1278100 | Doi | 10.1006/geno.1998.5402 |
| Citation | Thomson RB, et al. (1998) cDNA cloning and chromosomal localization of the human and mouse isoforms of Ksp-cadherin. Genomics 51(3):445-51 |
| abstractText | Ksp-cadherin is a novel kidney-specific member of the cadherin superfamily of cell adhesion molecules. We have determined the complete cDNA coding sequences of both the human and the mouse isoforms of Ksp-cadherin. The inferred amino acid sequences of the human and mouse isoforms are 79 and 75% identical to the originally described rabbit isoform of Ksp-cadherin (Thomson ct al., 1995; J. Biol. Chem. 270, 17594-17601), respectively. The relative locations of cadherin-specific sequence motifs, putative N- glycosylation sites, and characteristic protein domains are entirely conserved in all three isoforms. Multiple organ Northern analyses indicate that, as in the rabbit, both the human and the mouse Ksp-cadherin transcripts appear to have distinct kidney-specific distributions. The human Ksp-cadherin gene (CDH16) maps to chromosome 16q21- proximal 16q22. The mouse Ksp-cadherin gene (Cdh16) was localized to a highly syntenic region of distal Chromosome 8. Both the human and the mouse Ksp-cadherin genes were localized to previously identified clusters of cadherin gene sequences, consistent with the hypothesis that most cadherin family members arose by gene duplication from a single ancestral gene at a relatively early stage in the evolution of the mammalian genome. (C) 1998 Academic Press |
