| First Author | Funes S | Year | 2003 |
| Journal | Biochem Biophys Res Commun | Volume | 312 |
| Issue | 4 | Pages | 1357-63 |
| PubMed ID | 14652023 | Mgi Jnum | J:102113 |
| Mgi Id | MGI:3606823 | Doi | 10.1016/j.bbrc.2003.11.066 |
| Citation | Funes S, et al. (2003) The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system. Biochem Biophys Res Commun 312(4):1357-63 |
| abstractText | GPR54 is a G-protein-coupled receptor that displays a high percentage of identity in the transmembrane domains with the galanin receptors. The ligand for GPR54 has been identified as a peptide derived from the KiSS-1 gene. KiSS-1 has been shown to have anti-metastatic effects, suggesting that KiSS-1 or its receptor represents a potential therapeutic target. To further our understanding of the physiological function of this receptor, we have generated a mutant mouse line with a targeted disruption of the GPR54 receptor (GPR54 -/-). The analysis of the GPR54 mutant mice revealed developmental abnormalities of both male and female genitalia and histopathological changes in tissues which normally contain sexually dimorphic features. These data suggest a role for GPR54/KiSS-1 in normal sexual development, and indicate that study of the GPR54 mutant mice may provide valuable insights into human reproductive syndromes. |
