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Protein Coding Gene : Phip pleckstrin homology domain interacting protein

Primary Identifier  MGI:1932404 Organism  mouse, laboratory
Chromosome  9 NCBI Gene Number  83946
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable lysine-acetylated histone binding activity. Involved in several processes, including positive regulation of DNA-templated transcription; positive regulation of insulin-like growth factor receptor signaling pathway; and positive regulation of mitotic nuclear division. Acts upstream of or within several processes, including insulin receptor signaling pathway; positive regulation of cell population proliferation; and positive regulation of protein phosphorylation. Located in nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; female reproductive system; retina; and urinary system. Orthologous to human PHIP (pleckstrin homology domain interacting protein).
PHENOTYPE: Mice homozygous for a gene trapped allele exhibit postnatal and premature lethality associated with reduced body size, small myocardial cells and hepatocytes, hypoglycemia, increased insulin sensitivity, and reduced cell growth. [provided by MGI curators]
  • synonyms:
  • Wdr11,
  • MGI:1933643,
  • 4632404O06Rik,
  • RIKEN cDNA 2810004D21 gene,
  • MGI:1917187,
  • Ndrp,
  • RIKEN cDNA 4632404O06 gene,
  • MGI:1921594,
  • Phip,
  • neuronal differentiation related protein,
  • WD repeat domain 11,
  • pleckstrin homology domain interacting protein,
  • MGI:1926949,
  • 2810004D21Rik

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

1 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

6 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For