Primary Identifier | MGI:95774 | Organism | mouse, laboratory |
Chromosome | 18 | NCBI Gene Number | 14680 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Acts upstream of or within several processes, including adenylate cyclase-activating dopamine receptor signaling pathway; response to amphetamine; and response to caffeine. Predicted to be located in plasma membrane. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in cytoplasm. Is expressed in nervous system; sensory organ; and spleen. Human ortholog(s) of this gene implicated in dystonia 25. Orthologous to human GNAL (G protein subunit alpha L). PHENOTYPE: Homozygous for a targeted mutation fail to feed, and ~75% die within 2 days after birth. Rare survivors reach sexual maturity and mate but are hyperactive and anosmic, exhibitng severely reduced odor-evoked electrophysical responses and significantly perturbed maternal behaviors. [provided by MGI curators] |