| First Author | Schwindinger WF | Year | 2003 |
| Journal | J Biol Chem | Volume | 278 |
| Issue | 8 | Pages | 6575-9 |
| PubMed ID | 12488442 | Mgi Jnum | J:81988 |
| Mgi Id | MGI:2450485 | Doi | 10.1074/jbc.M211132200 |
| Citation | Schwindinger WF, et al. (2003) Loss of G protein gamma 7 alters behavior and reduces striatal alpha(olf) level and cAMP production. J Biol Chem 278(8):6575-9 |
| abstractText | The G protein beta gamma-dimer is required for receptor interaction and effector regulation. However, previous approaches have not identified the physiologic roles of individual subtypes in these processes. We used a gene knockout approach to demonstrate a unique role for the G protein gamma(7)-subunit in mice. Notably, deletion of Gng7 caused behavioral changes that were associated with reductions in the alpha(olf)-subunit content and adenylyl cyclase activity of the striatum. These data demonstrate that an individual gamma-subunit contributes to the specificity of a given signaling pathway and controls the formation or stability of a particular G protein heterotrimer. |
