| Primary Identifier | MGI:1891433 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 74585 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity. Involved in T cell receptor signaling pathway; positive regulation of calcineurin-NFAT signaling cascade; and positive regulation of cytosolic calcium ion concentration. Located in endoplasmic reticulum-Golgi intermediate compartment membrane. Is expressed in central nervous system; gonad; retina; and vibrissa. Orthologous to human SPPL3 (signal peptide peptidase like 3). PHENOTYPE: Mice homozygous for a gene trap insertion exhibit growth retardation, reduced fertility and behavioral abnormalities. Mice homozygous for a constitutive null allele or a protease-dead allele show neonatal and postnatal lethality. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
