| Primary Identifier | MGI:1351342 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 108071 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential and neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration. Involved in several processes, including calcium-mediated signaling using intracellular calcium source; cellular response to amyloid-beta; and learning or memory. Acts upstream of or within learning; locomotory behavior; and regulation of long-term neuronal synaptic plasticity. Located in cytoplasm; neuron projection; and plasma membrane. Is active in Schaffer collateral - CA1 synapse. Is expressed in central nervous system and retina. Used to study schizophrenia. Orthologous to human GRM5 (glutamate metabotropic receptor 5). PHENOTYPE: Homozygous null mice have reduced corticostriatal long term potentiation, do not exhibit hyperactivity after cocaine consumption and do not self-administer cocaine. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
