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Allele : Gja1<tm2(Gjb1)Kwi> gap junction protein, alpha 1; targeted mutation 2, Klaus Willecke

Primary Identifier  MGI:2386240 Allele Type  Targeted
Attribute String  Inserted expressed sequence, Null/knockout Gene  Gja1
Transmission  Germline Strain of Origin  129P2/OlaHsd-Hprt1<b-m3>
Is Recombinase  false Is Wild Type  false
molecularNote  The endogenous gene was deleted and replaced with Gjb1 genomic sequence extending from 158 bp upstream of the start codon to 171 bp downstream of the stop codon. RT-PCR verified the ablation of endogenous expression and showed that the Gjb1 sequence was transcribed. The absence of endogenous protein was demonstrated by Western blot ananlysis of brain tissue, which also confirmed the presence of the Gjb1 protein.
  • mutations:
  • Intragenic deletion,
  • Insertion
  • synonyms:
  • Cx43KI32,
  • Cx43KI32
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

11 Publication categories

Trail: Allele