| First Author | Huang MT | Year | 1995 |
| Journal | Int Rev Immunol | Volume | 13 |
| Issue | 1 | Pages | 29-41 |
| PubMed ID | 7494107 | Mgi Jnum | J:31056 |
| Mgi Id | MGI:78517 | Doi | 10.3109/08830189509061736 |
| Citation | Huang MT (1995) T cell development in CD3-zeta mutant mice. Int Rev Immunol 13(1):29-41 |
| abstractText | Increasing evidence points to multiple pathways of T lymphocyte development. The well characterized thymus-dependent pathway gives rise to T cells bearing TCR alpha beta heterodimers and either CD4 or CD8 alpha beta co-receptors. T cells of this lineage populate peripheral lymphoid compartments including lymph nodes, spleen, skin, and Peyer's patches. By comparison, factors which govern extrathymic T cell development are poorly understood. A variety of experiments have shown that intestinal intraepithelial lymphocytes (IELs) develop outside of the thymic environment, e.g., in the gut of nude, SCID, and beta 2m-/- mutant mice, and after transplanting bone marrow or fetal liver cells into irradiated thymectomized adult mice. This review focuses on the role of the CD3-zeta subunit in the development of both thymically and extrathymically derived T cells as determined by gene-targeting experiments in mice. Data from these and other T cell-related mutations continue to define crucial stages in thymocyte differentiation. Most interestingly, CD3-zeta mutant mice contain a unique population of intestinal IELs that develops independently of thymic selective processes and expresses a novel TCR/CD3 complex. |
