| First Author | Hinck L | Year | 1994 |
| Journal | Trends Biochem Sci | Volume | 19 |
| Issue | 12 | Pages | 538-42 |
| PubMed ID | 7846766 | Mgi Jnum | J:21875 |
| Mgi Id | MGI:69776 | Doi | 10.1016/0968-0004(94)90057-4 |
| Citation | Hinck L, et al. (1994) Beta-catenin: a common target for the regulation of cell adhesion by Wnt-1 and Src signaling pathways. Trends Biochem Sci 19(12):538-42 |
| abstractText | Beta-catenin is a cytosolic protein originally identified through its association with the cadherin class of cell-adhesion proteins. However, recent studies have demonstrated that there are cadherin-independent pools of beta-catenin and that beta-catenin binds at least one other protein, the product of the tumor-suppressor gene APC. Furthermore, beta-catenin is the target of two signal transduction pathways mediated by the proto-oncogenes src and wnt-1. This raises the possibility that beta-catenin plays a pivotal role in balancing cellular responses to both adhesive and proliferative signals. |
