| First Author | Chang HS | Year | 1996 |
| Journal | Nucleic Acids Res | Volume | 24 |
| Issue | 7 | Pages | 1360-8 |
| PubMed ID | 8614642 | Mgi Jnum | J:32575 |
| Mgi Id | MGI:80069 | Doi | 10.1093/nar/24.7.1360 |
| Citation | Chang HS, et al. (1996) Positive elements in the laminin gamma 1 gene synergize to activate high level transcription during cellular differentiation. Nucleic Acids Res 24(7):1360-8 |
| abstractText | Transcription of the murine laminin gamma 1 gene is activated during retinoic acid/cAMP induced differentiation of F9 embryonal carcinoma cells. Positive transcription control elements associated with two DNase I hypersensitive regions in the large first intron of the gene have been identified which confer a differentiation response on the laminin gamma 1 promoter. However, the kinetics of transcriptional activation suggest each DNA region interacts with transcription factors appearing at different times during differentiation. Synergy between the two regions in cis causes high level activation. |
