Primary Identifier | MGI:98857 | Organism | mouse, laboratory |
Chromosome | 15 | NCBI Gene Number | 22122 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable GDP-L-fucose synthase activity; GDP-mannose 3,5-epimerase activity; and identical protein binding activity. Acts upstream of or within T cell mediated cytotoxicity. Orthologous to human GFUS (GDP-L-fucose synthase). PHENOTYPE: Homozygotes for a targeted null mutation frequently die in utero, while survivors are smaller than normal, show colon abnormalities, have reduced fertility, and frequently die before weaning. Heterozygotes also show some embryonic loss. [provided by MGI curators] |