| First Author | Murray DA | Year | 2004 |
| Journal | J Immunol | Volume | 173 |
| Issue | 4 | Pages | 2402-9 |
| PubMed ID | 15294953 | Mgi Jnum | J:92683 |
| Mgi Id | MGI:3054297 | Doi | 10.4049/jimmunol.173.4.2402 |
| Citation | Murray DA, et al. (2004) TNF-alpha controls intrahepatic T cell apoptosis and peripheral T cell numbers. J Immunol 173(4):2402-9 |
| abstractText | At the end of an immune response, activated lymphocyte populations contract, leaving only a small memory population. The deletion of CD8(+) T cells from the periphery is associated with an accumulation of CD8(+) T cells in the liver, resulting in both CD8(+) T cell apoptosis and liver damage. After adoptive transfer and in vivo activation of TCR transgenic CD8(+) T cells, an increased number of activated CD8(+) T cells was observed in the lymph nodes, spleen, and liver of mice treated with anti-TNF-alpha. However, caspase activity was decreased only in CD8(+) T cells in the liver, not in those in the lymphoid organs. These results indicate that TNF-alpha is responsible for inducing apoptosis in the liver and suggest that CD8(+) T cells escaping this mechanism of deletion can recirculate into the periphery. |
