Primary Identifier | MGI:1346321 | Organism | mouse, laboratory |
Chromosome | 16 | NCBI Gene Number | 23794 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Enables extracellular matrix binding activity; heparin binding activity; and peptidase activity. Involved in several processes, including heart development; myoblast fusion; and negative regulation of cold-induced thermogenesis. Acts upstream of or within defense response to bacterium. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and immune system. Human ortholog(s) of this gene implicated in osteoarthritis. Orthologous to human ADAMTS5 (ADAM metallopeptidase with thrombospondin type 1 motif 5). PHENOTYPE: Mice homozygous for one null allele exhibit a significant reduction in cartilage degradation after induction of osteoarthritis whereas those homozygous for another show no affect. [provided by MGI curators] |