| First Author | Kimura M | Year | 2001 |
| Journal | Scand J Immunol | Volume | 54 |
| Issue | 6 | Pages | 613-8 |
| PubMed ID | 11902337 | Mgi Jnum | J:79636 |
| Mgi Id | MGI:2388686 | Doi | 10.1046/j.1365-3083.2001.01016.x |
| Citation | Kimura M, et al. (2001) Ontogeny of the murine Ig joining chain gene and protein. Scand J Immunol 54(6):613-8 |
| abstractText | We used Northern blot analysis in order to investigate the ontogeny of the murine joining (J)-chain gene. No J-chain expression was detected in embryonic tissues, including liver, spleen and intestine, but an expression of mu heavy chain was detected in foetal liver at day 17. J-chain expression was detected in the spleen at day 9 and in the intestine at day 15 after birth. Western blot analysis was carried out in order to compare the protein levels of J and mu heavy chains in serum from day 8 to day 24 after birth, using antihuman J chain and antimouse mu chain antibodies. Although mu chain protein could be detected in serum from day 8, J-chain protein was detectable only at day 24. These results suggest that the expression of J chain is a later event than the mu chain in the mouse, which thus differs in embryogenesis from humans. |
