| First Author | Wadhwa R | Year | 2003 |
| Journal | Exp Gerontol | Volume | 38 |
| Issue | 3 | Pages | 245-52 |
| PubMed ID | 12581788 | Mgi Jnum | J:82181 |
| Mgi Id | MGI:2651736 | Doi | 10.1016/s0531-5565(02)00180-8 |
| Citation | Wadhwa R, et al. (2003) A novel putative collaborator of p19(ARF). Exp Gerontol 38(3):245-52 |
| abstractText | We performed a yeast interactive screen in search of p19(ARF)-binding partners and have isolated a novel serine rich protein that is assigned to human chromosome 4q35 and mouse chromosome 8. The human and mouse proteins showed 84.2% homology. It is named CARF for its role as a putative Collaborator of ARF. CARF binds to both mouse and human ARF proteins. Its expression was detected in a variety of human tissues. The cDNA was expressed in bacteria and mammalian cells as a soluble and predominantly nuceloplasmic protein, respectively. CARF is a novel binding partner of ARF and might be involved in its p53-dependent or -independent tumor suppressive functions. |
