| Primary Identifier | IPR011176 | Type | Family |
| Short Name | CCP_VACV_C3/B5 |
| description | This group represents complement control proteins, vaccinia virus C3-type. The vaccinia virus complement control protein C3 is involved in modulating the host inflammatory response by blocking both classical and alternative pathways of complement activity through its ability to bind host complement components C3b and C4b (complement 3b and 4b, respectively) []. Protein B5, another member of this group, binds complement components C3 and C1q []. By blocking complement activation at multiple sites, the complement control proteins can down-regulate pro-inflammatory chemotactic factors (C3a, C4a, and C5a), resulting in reduced cellular influx and inflammation.. |
