| First Author | Baserga R | Year | 1999 |
| Journal | Exp Cell Res | Volume | 253 |
| Issue | 1 | Pages | 1-6 |
| PubMed ID | 10579905 | Mgi Jnum | J:58736 |
| Mgi Id | MGI:1349539 | Doi | 10.1006/excr.1999.4667 |
| Citation | Baserga R (1999) The IGF-I receptor in cancer research. Exp Cell Res 253(1):1-6 |
| abstractText | The type 1 insulin-like growth factor receptor (IGF-IR) plays an important role in both normal and abnormal growth. It is particularly important in anchorage-independent growth. Impairment of its function causes apoptosis of tumor cells and inhibition of tumor growth in experimental animals. However, the IGF-IR can also induce differentiation, and eventually cell death, of certain types of cells. Its major substrates, IRS-1 and Shc, determine whether the IGF-IR will transform cells or will cause their differentiation. Copyright 1999 Academic Press. |
