| Primary Identifier | MGI:98217 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 20203 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable several functions, including RAGE receptor binding activity; S100 protein binding activity; and metal ion binding activity. Involved in several processes, including adaptive thermogenesis; positive regulation of neuron differentiation; and sympathetic neuron projection extension. Acts upstream of or within memory and regulation of neuronal synaptic plasticity. Located in cytoplasm; neuronal cell body; and nucleus. Is active in extracellular region. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; aspergillosis; and schizophrenia. Orthologous to human S100B (S100 calcium binding protein B). PHENOTYPE: Homozygotes for targeted null mutations exhibit enhanced spatial memory, fear memory, and long-term potentiation in the hippocampal CA1 region, and more rapid and severe seizures as the result of an amygdala kindling paradigm. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
