| Primary Identifier | MGI:109172 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 666279 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable collagen binding activity. Acts upstream of or within several processes, including epithelial cell differentiation; nephron morphogenesis; and odontogenesis of dentin-containing tooth. Located in extracellular matrix; extracellular space; and nucleus. Is expressed in several structures, including central nervous system; gut; jaw; lung; and metanephros. Used to study dentinogenesis imperfecta and periodontal disease. Human ortholog(s) of this gene implicated in dentinogenesis imperfecta. Orthologous to human DSPP (dentin sialophosphoprotein). PHENOTYPE: Aging mice homozygous for a reporter/null allele display tooth abnormalities, including enlarged pulp cavities, a widened predentin zone, dentin hypomineralization, pulp exposure, and occasional brittle incisors. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
