| First Author | Lyu J | Year | 2008 |
| Journal | Dev Cell | Volume | 15 |
| Issue | 5 | Pages | 773-80 |
| PubMed ID | 19000841 | Mgi Jnum | J:142801 |
| Mgi Id | MGI:3822212 | Doi | 10.1016/j.devcel.2008.10.004 |
| Citation | Lyu J, et al. (2008) Cleavage of the Wnt receptor Ryk regulates neuronal differentiation during cortical neurogenesis. Dev Cell 15(5):773-80 |
| abstractText | Ryk is a transmembrane receptor tyrosine kinase (RTK). It functions as a receptor of Wnt proteins required for cell-fate determination, axon guidance, and neurite outgrowth in different organisms; however, the molecular mechanism of Ryk signaling is unknown. Here, we show that Ryk is cleaved, permitting the intracellular C-terminal fragment of Ryk to translocate to the nucleus in response to Wnt3 stimulation. We also show that the cleaved intracellular domain of Ryk is required for Wnt3-induced neuronal differentiation in vitro and in vivo. These results demonstrate an unexpected mechanism of signal transduction for Ryk as a Wnt receptor, in which the intracellular domain itself functions as the transducing molecule to bring extracellular signals from the cell surface into the nucleus, to regulate neural progenitor cell differentiation. |
