| First Author | Hawkins ED | Year | 2013 |
| Journal | Nat Commun | Volume | 4 |
| Pages | 1801 | PubMed ID | 23653213 |
| Mgi Jnum | J:338641 | Mgi Id | MGI:6852252 |
| Doi | 10.1038/ncomms2796 | Citation | Hawkins ED, et al. (2013) Regulation of asymmetric cell division and polarity by Scribble is not required for humoral immunity. Nat Commun 4:1801 |
| abstractText | The production of protective antibody requires effective signalling of naive B cells following encounter with antigen, and the divergence of responding B lymphocytes into distinct lineages. Polarity proteins have recently been proposed as important mediators of both the initial B cell response, and potentially of asymmetric cell division. Here we show that, although polarity proteins of the Scribble complex, Scribble, Dlg1 and Lgl1, are expressed and polarized during early B cell activation, their deficiency has no effect on the in vivo outcome of immunization or challenge with influenza infection. Furthermore, we find a striking correlation in the differentiation outcome of daughters of single founder B cells in vitro. Taken together, our results indicate that B cell differentiation does not require polarity proteins of the Scribble complex, and the findings do not support a role for asymmetric cell division in B cell activation and differentiation. |
