| First Author | Chan AM | Year | 1988 |
| Journal | Oncogene | Volume | 2 |
| Issue | 6 | Pages | 593-9 |
| PubMed ID | 2838789 | Mgi Jnum | J:13364 |
| Mgi Id | MGI:61565 | Citation | Chan AM, et al. (1988) Characterization of the mouse met proto-oncogene. Oncogene 2(6):593-9 |
| abstractText | The DNA sequence of cDNA clones prepared from transcripts of the mouse met proto-oncogene reveals that the mouse met gene encodes a 1380 amino acid protein with the characteristics of a growth factor receptor. This protein can be divided into several putative domains, including an intracellular protein tyrosine kinase domain, a transmembrane domain and a 929 amino acid extracellular domain, possessing a potential proteolytic cleavage site with the sequence Lys-Arg-Arg-Lys-Arg-Ser. To gain additional insights into the function of the met protein we have examined the level of met transcripts in tissues of the late-gestation mouse conceptus. Transcription of met was observed in most of the tissues analysed, but the highest levels of met mRNA were detected in the yolk sac, amnion and kidney; no transcripts were detectable in the calvaria. Chromosomal localization using a series of mouse-hamster hybrid cell lines has demonstrated that met is located on mouse chromosome 6. |
