| First Author | Dreiding P | Year | 1985 |
| Journal | Virology | Volume | 140 |
| Issue | 1 | Pages | 192-6 |
| PubMed ID | 3880978 | Mgi Jnum | J:7703 |
| Mgi Id | MGI:56172 | Doi | 10.1016/0042-6822(85)90460-x |
| Citation | Dreiding P, et al. (1985) Interferon-induced protein Mx accumulates in nuclei of mouse cells expressing resistance to influenza viruses. Virology 140(1):192-6 |
| abstractText | In mouse cells carrying the dominant influenza resistance allele Mx+ (but not in Mx- cells) interferon-alpha/beta (IFN) induces an efficient antiviral state against influenza viruses and, concomitantly, the synthesis of a 75,000-Da protein (protein Mx). Here, indirect immunofluorescence using monoclonal antibodies was used to demonstrate that protein Mx accumulates in the nucleus of IFN-treated Mx+ cells, suggesting a nuclear site of action. Protein Mx is present in the nucleus of untreated influenza virus-resistant macrophages freshly explanted from the peritoneal cavity of Mx+ mice but is lost with time in culture when peritoneal macrophages become permissive for influenza virus. |
