| First Author | Hanasaki K | Year | 1997 |
| Journal | J Biol Chem | Volume | 272 |
| Issue | 52 | Pages | 32792-7 |
| PubMed ID | 9407054 | Mgi Jnum | J:44868 |
| Mgi Id | MGI:1101414 | Doi | 10.1074/jbc.272.52.32792 |
| Citation | Hanasaki K, et al. (1997) Resistance to endotoxic shock in phospholipase A2 receptor-deficient mice. J Biol Chem 272(52):32792-7 |
| abstractText | Mammals possess various types of secretory phospholipase A2, which differ in the primary structure and tissue distribution. The phosholipase A2 receptor (PLA2R) recognizes group IB phospholipase A2 (PLA2-IB) and mediates the PLA2-IB-induced biological responses in non-digestive organs, including eicosanoid production and contraction of airway smooth muscles. In this study, we generated PLA2R-deficient mice to define its biological roles further. These mice are viable, fertile, and without evident histopathological abnormalities. There was no difference in the clearance of circulating PLA2-IB between wild-type and mutant mice. After challenge with bacterial lipopolysaccharide (LPS), PLA2R-deficient mice exhibited longer survival than wild-type mice. The mutant mice were also resistant to lethal effects of exogenous PLA2-IB after sensitization with sublethal dose of LPS. The plasma levels of tumor necrosis factor-alpha and interleukin-1beta elevated after LPS treatment were significantly reduced in mutant mice compared with wild-type mice. These findings suggest a potential role of PLA2R in the progression of endotoxic shock. |
