| Primary Identifier | MGI:97527 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 18590 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable several functions, including platelet-derived growth factor binding activity; protein dimerization activity; and signaling receptor binding activity. Involved in digestive tract development; embryonic lung development; and lung alveolus development. Acts upstream of or within several processes, including hair follicle development; positive regulation of mesenchymal cell proliferation; and regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling. Located in extracellular space and microvillus. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human PDGFA (platelet derived growth factor subunit A). PHENOTYPE: Homozygotes for a targeted null mutation die either before E10.0 or postnatally. The latter exhibit lung emphysema, reduced numbers of oligodendrocytes, tremors, and abnormalities of the skin, hair follicles, and gastrointestinal lining. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
