Primary Identifier | MGI:6759468 | Allele Type | Targeted |
Gene | Esr1 | Transmission | Germline |
Strain of Origin | 129P2/OlaHsd | Is Recombinase | false |
Is Wild Type | false |
molecularNote | A cysteine to alanine mutation at residue 451 (C451A) and a neomycin selection cassette flanked by FRT sites were inserted into the locus. Flp-mediated recombination removed the neomycin cassette. This mutation abolishes palmitoylation and membrane trafficking of the receptor. |