| First Author | Konoshima T | Year | 2001 |
| Journal | Biol Pharm Bull | Volume | 24 |
| Issue | 12 | Pages | 1440-2 |
| PubMed ID | 11767120 | Mgi Jnum | J:73534 |
| Mgi Id | MGI:2155636 | Doi | 10.1248/bpb.24.1440 |
| Citation | Konoshima T, et al. (2001) Anti-tumor-Promoting activity of the diterpene from Excoecaria agallocha. II. Biol Pharm Bull 24(12):1440-2 |
| abstractText | Eight new diterpenoids (1-8) have been isolated from the wood of Excoecaria agallocha (Euphorbiaceae) and their inhibitory effects on the induction of Epstein-Barr virus early antigen (EBV-EA) in Raji cells were examined to search for potent anti-tumor-promoters from natural resources. Of these compounds, the secolabdane-type diterpenoid, compound 7 exhibited a remarkable inhibitory effect on EBV-EA induction, and a significant anti-tumor-promoting effect in the mouse two-stage carcinogenesis test using 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanovl-phorbol-13-acetate. |
