| First Author | Garibay D | Year | 2018 |
| Journal | Cell Rep | Volume | 23 |
| Issue | 4 | Pages | 967-973 |
| PubMed ID | 29694904 | Mgi Jnum | J:271285 |
| Mgi Id | MGI:6278506 | Doi | 10.1016/j.celrep.2018.03.120 |
| Citation | Garibay D, et al. (2018) beta Cell GLP-1R Signaling Alters alpha Cell Proglucagon Processing after Vertical Sleeve Gastrectomy in Mice. Cell Rep 23(4):967-973 |
| abstractText | Bariatric surgery, such as vertical sleeve gastrectomy (VSG), causes high rates of type 2 diabetes remission and remarkable increases in postprandial glucagon-like peptide-1 (GLP-1) secretion. GLP-1 plays a critical role in islet function by potentiating glucose-stimulated insulin secretion; however, the mechanisms remain incompletely defined. Therefore, we applied a murine VSG model to an inducible beta cell-specific GLP-1 receptor (GLP-1R) knockout mouse model to investigate the role of the beta cell GLP-1R in islet function. Our data show that loss of beta cell GLP-1R signaling decreases alpha cell GLP-1 expression after VSG. Furthermore, we find a beta cell GLP-1R-dependent increase in alpha cell expression of the prohormone convertase required for the production of GLP-1 after VSG. Together, the findings herein reveal two concepts. First, our data support a paracrine role for alpha cell-derived GLP-1 in the metabolic benefits observed after VSG. Second, we have identified a role for the beta cell GLP-1R as a regulator of alpha cell proglucagon processing. |
