| First Author | Sun X | Year | 2008 |
| Journal | Biochem Biophys Res Commun | Volume | 377 |
| Issue | 4 | Pages | 1097-101 |
| PubMed ID | 18977203 | Mgi Jnum | J:177251 |
| Mgi Id | MGI:5294538 | Doi | 10.1016/j.bbrc.2008.10.109 |
| Citation | Sun X, et al. (2008) Akt activation prevents Apop-1-induced death of cells. Biochem Biophys Res Commun 377(4):1097-101 |
| abstractText | Apop-1 is a novel protein identified in cultured atherosclerotic smooth muscle cells of ApoE-deficient mice, and the expression of the Apop-1 protein induces the death of cultured cells. Insulin-like growth factor-1 (IGF-1) is a well-characterized survival factor for VSMC; however, the interaction between Apop-1 and survival factor IGF-1 in the mediation of cell death is poorly understood. In this report, we show that the IGF-1 signaling cascade protects VSMC against Apop-1-induced death. Furthermore, our data indicate that the inhibition of Apop-1-induced death by IGF-1 is mediated by the activation of the PI3K/Akt signaling pathway. |
