| First Author | Arens R | Year | 2001 |
| Journal | Immunity | Volume | 15 |
| Issue | 5 | Pages | 801-12 |
| PubMed ID | 11728341 | Mgi Jnum | J:73129 |
| Mgi Id | MGI:2154603 | Doi | 10.1016/s1074-7613(01)00236-9 |
| Citation | Arens R, et al. (2001) Constitutive CD27/CD70 Interaction Induces Expansion of Effector-Type T Cells and Results in IFNgamma-Mediated B Cell Depletion. Immunity 15(5):801-12 |
| abstractText | The interaction between the TNF receptor family member CD27 and its ligand CD70 provides a costimulatory signal for T cell expansion. Normally, tightly regulated expression of CD70 ensures the transient availability of this costimulatory signal. Mice expressing constitutive CD70 on B cells had higher peripheral T cell numbers that showed increased differentiation toward effector-type T cells. B cell numbers in CD70 transgenic (TG) mice progressively decreased in primary and secondary lymphoid organs. This B cell depletion was caused by CD27-induced production of IFNgamma in T cells. We conclude that apart from its role in controlling the size of the activated T cell pool, CD27 ligation contributes to immunity by facilitating effector T cell differentiation. |
