Primary Identifier | MGI:1921941 | Organism | mouse, laboratory |
Chromosome | 12 | NCBI Gene Number | 74691 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables ATP hydrolysis activity. Involved in several processes, including male meiosis I; piRNA processing; and retrotransposon silencing by heterochromatin formation. Acts upstream of or within retrotransposon silencing. Located in nucleus and piP-body. Is expressed in germ cell of testis. Human ortholog(s) of this gene implicated in spermatogenic failure 30. Orthologous to human TDRD9 (tudor domain containing 9). PHENOTYPE: Male homozygous mice are sterile, displaying small testis, arrest of male meiosis and abnormal spermatocyte morphology. Females are fertile. [provided by MGI curators] |