| Type | MGI:General | Description | in an in vitro transmission model in which alpha-synuclein preformed fibrils are used to seed endogenous alpha-synuclein into Lewy-like inclusions, neurons accumulate increased alpha-synuclein phosphorylated at S129 2 weeks after exposure compared to wild-type neurons; this accumulation of alpha-synuclein leads to increased damage to the integrity of lysosomal membranes in neurons |
