| First Author | Hogarth PM | Year | 1985 |
| Journal | J Immunol | Volume | 135 |
| Issue | 3 | Pages | 1632-6 |
| PubMed ID | 3160773 | Mgi Jnum | J:7940 |
| Mgi Id | MGI:56409 | Doi | 10.4049/jimmunol.135.3.1632 |
| Citation | Hogarth PM, et al. (1985) The distribution of the Qa-2 alloantigen on functional T lymphocytes. J Immunol 135(3):1632-6 |
| abstractText | The expression of Qa-2 on functional lymphocytes was investigated in vitro and in vivo by using a monoclonal anti-Qa-2 antibody. In vitro treatment of T cells with antibody and complement demonstrated that T cells mediating help or delayed-type hypersensitivity for anti-SRBC responses were Qa-2+. In addition, cytotoxic T cells and either their precursors or cells involved in their generation were Qa-2+, as were anti-HGG suppressor T cells. Panning techniques were also used to show that secondary suppressor T cells were Qa-2+ and that there may be heterogeneity in suppressor T cells defined by Qa-2 expression. In vivo treatment of mice with anti-Qa-2 resulted in decrease in immune responsiveness seen by i) prolongation of skin grafts with either H-2D or I-A differences, ii) suppression of delayed-type hypersensitivity, and iii) inhibition of T cell-mediated suppression. Finally, IgG, but not IgM, anti-body-forming cells were Qa-2+. |
