| Primary Identifier | MGI:106675 | Organism | mouse, laboratory |
| Chromosome | 16 | NCBI Gene Number | 11450 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables hormone activity; identical protein binding activity; and protein serine/threonine kinase activator activity. Involved in several processes, including detection of oxidative stress; negative regulation of cold-induced thermogenesis; and negative regulation of metanephric mesenchymal cell migration. Acts upstream of or within with a positive effect on gene expression. Acts upstream of or within several processes, including brown fat cell differentiation; negative regulation of gluconeogenesis; and positive regulation of canonical NF-kappaB signal transduction. Located in endoplasmic reticulum and extracellular space. Is expressed in several structures, including adipose tissue; early conceptus; gut; reproductive system; and serum. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); liver disease (multiple); primary open angle glaucoma; prostate adenocarcinoma; and type 2 diabetes mellitus. Orthologous to human ADIPOQ (adiponectin, C1Q and collagen domain containing). PHENOTYPE: Homozygotes for targeted null mutations exhibit increased beta-oxidation in muscle and liver, impaired free fatty acid clearance, and moderate insulin resistance. Heterozygotes show mild insulin resistance. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
