| First Author | Arentson E | Year | 2002 |
| Journal | Oncogene | Volume | 21 |
| Issue | 8 | Pages | 1150-8 |
| PubMed ID | 11850834 | Mgi Jnum | J:75006 |
| Mgi Id | MGI:2159541 | Doi | 10.1038/sj.onc.1205175 |
| Citation | Arentson E, et al. (2002) Oncogenic potential of the DNA replication licensing protein CDT1. Oncogene 21(8):1150-8 |
| abstractText | The expression of a gene, designated as Retroviral insertion site (Ris)2, was activated by retroviral DNA integration in an immortalized primitive erythroid cell line, EB-PE. Ris2 was also expressed at high levels in all human tumor cell lines analysed. Consistently, NIH3T3 fibroblasts overexpressing Ris2 formed tumors in Rag2 -/- mice when injected subcutaneously. The putative RIS2 protein shows a high sequence similarity to Xenopus CDT1, Drosophila DUP, and human CDT1, a newly identified DNA replication licensing protein, suggesting that Ris2 is a mouse homologue of CDT1. Cells overexpressing Ris2/Cdt1 exhibited a quicker entry into S phase when released from serum starvation compared to controls. Our results suggest that CDT1, an essential licensing protein for DNA replication, can function as an oncogene in mammals. |
